HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2076804Generated: October 30, 2026
4-Chlorobenzaldehyde → 4-(Benzenesulfonyl)benzaldehyde
https://huagongshe.com/reaction/2076804
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chlorobenzaldehyde | HCID 7726 | — |
| Reactant | Benzenesulfinic acid, sodium salt | HCID 2723840 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-(Benzenesulfonyl)benzaldehyde | HCID 14417477 | 76.5% |
Reaction Steps
A microwave vessel was charged with 1 g of 4-chlorobenzaldehyde in 6 mL of DMSO and 1.75 g of sodium benzenesulfinate. The vessel was sealed and heated in a microwave reactor at 180° C. for 1.5 hours. The mixture was cooled and poured into 12 mL of ice water. Filtered and the solid was purified by flash chromatography using ethyl acetate/hexane as eluent mixtures to afford 1.34 g of the title compound. 76% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07928103B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-d01eb62a3a674d85a96f5d8c6e30ec59 |
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| Source note | uspto-grants-2011_04 |
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