HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-5-pyrimidinecarboxamide → HCID 135923523, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-5-pyrimidinecarboxamide | HCID 818212 | — |
| Reactant | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Reactant | (2-m-Tolyl-ethoxy)-acetic acid methyl ester | HCID 67099145 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 135923523 | HCID 135923523 | — |
Reaction Steps
In analogy to example 3.3, 4-amino-5-pyrimidinecarboxamide and (2-m-tolyl-ethoxy)-acetic acid methyl ester (prepared from 2-m-tolyl-ethanol [1875-89-4] in analogy to example 3.1-3.2) reacted in the presence of LiHMDS in THF to yield the title compound (after purification of the crude product with column chromatography (silica gel, EtOAc/MeOH) and crystallization from TBME) as white solid. MS: m/e=295.5 [M−H−].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928106B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-ca34c62bdfdf40b38c1e7d6eb9faadd6 |
| Source note | uspto-grants-2011_04 |