Hydrochloric Acid → HCID 135923524, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of crude 3-chloro-pyrazine-2-carboxylic acid{2-[2-(3-chloro-4-fluoro-phenyl)-ethoxy]-1-imino-ethyl}-amide (300 mg) and K2CO3 (223 mg, 1.616 mmol) in DMF (3 ml) was heated to 100° C. for 2 h. Then water was added and the pH was adjusted to 5 by addition of 0.1 N HCl. The brown precipitate that formed was filtered off, washed with water and dried. The resulting solid was triturated with Et2O. The remaining solid was filtered off, washed with a small amount of Et2O and dried to give the title compound as a light brown solid (122 mg, 45%). MS: m/e=335.2 [M+H+].

Provenance & Evidence