Hydrochloric Acid → HCID 135923533, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of crude 3,6-dichloro-pyridazine-4-carboxylic acid{2-[2-(3-chloro-phenyl)-ethoxy]-1-imino-ethyl}-amide (170 mg) and K2CO3 (121 mg, 0.877 mmol) in DMF (2 ml) was heated to 100° C. for 2 h. Then water was added and the pH was adjusted to 2 by addition of 0.1 N HCl. The resulting mixture was extracted two times with CH2Cl2 and the combined extracts were washed with water and brine, dried (Na2SO4) and evaporated. The remaining residue was purified by column chromatography (silica gel, CH2Cl2/MeOH 100:0 to 98:2) to give the title compound as light yellow solid (1 mg, 0.5%). MS: m/e=351.1 [M+H+].

Provenance & Evidence