反应详情

6-Oxo-1,4,5,6-tetrahydro-[1,2,4]triazine-5-carboxylic acid ethyl ester (329 mg, 1.92 mmol) was dissolved in ethanol (9 ml) and diacetoxyiodosobenzene (644 mg, 1.99 mmol) was added in one portion. After 2 h at ambient temperature all volatiles were removed and the remaining residue was purified by column chromatography (silica gel, heptane/ethyl acetate 70:30 to 50:50) to give the title compound (209 mg, 1.24 mmol; 64%) as yellow solid. MS: m/e=170.1 [M+H+].

1. customAfter 2 h at ambient temperature all volatiles were removed
2. customthe remaining residue was purified by column chromatography (silica gel, heptane/ethyl acetate 70:30 to 50:50)