HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 5-Fluoro-4-piperidino-6-(2-pentynyloxy)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine | HCID 59341120 | — |
| Product | 5-Fluoro-4-piperidino-6-(2-pentynyloxy)pyrimidine | HCID 59341134 | 97.8% |
Reaction Steps
0.2 g of 4-chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine and 0.24 g of piperidine were mixed and left for 3 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.24 g of 5-fluoro-4-piperidino-6-(2-pentynyloxy)pyrimidine (hereinafter, referred to as Compound (12)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928110B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-ff6d08e03423427b8ae5a5c5373095af |
| Source note | uspto-grants-2011_04 |