2-Ethylpiperidine → 4-(2-Butynyloxy)-6-(2-ethylpiperidino)pyrimidine

HRID 2076858Notes

Reaction equation

HRID 2076858 reaction equation
Cl[C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]#[C:11][CH3:12])[N:5]=[CH:4][N:3]=1.[CH2:13]([CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][NH:16]1)[CH3:14]>>[CH2:9]([O:8][C:6]1[CH:7]=[C:2]([N:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH:15]2[CH2:13][CH3:14])[N:3]=[CH:4][N:5]=1)[C:10]#[C:11][CH3:12]

Participants

3

Reactant 2

HCID 942052-EthylpiperidineHCID 121376024-(2-Butynyloxy)-6-chloropyrimidine

Product 1

HCID 593411364-(2-Butynyloxy)-6-(2-ethylpiperidino)pyrimidineYield 32.9%

Procedure

0.3 g of 4-chloro-6-(2-butynyloxy)pyrimidine and 0.56 g of 2-ethylpiperidine were mixed and left for 18 hours at 80° C. The reaction mixture was cooled to near room temperature and subjected to silica gel column chromatography to obtain 0.14 g of 4-(2-butynyloxy)-6-(2-ethylpiperidino)pyrimidine (hereinafter, referred to as Compound (22)).

Sources & evidence

ORD record
ord-e26f956b56704696b31a064f96597665
Source dataset
uspto-grants-2011_04
Patent number
US07928110B2

Reaction notes

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