HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dimethylpiperidine → 4-Chloro-6-(cis-3,5-dimethylpiperidino)-5-fluoropyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dimethylpiperidine | HCID 118259 | — |
| Reactant | 4,6-Dichloro-5-fluoropyrimidine | HCID 11286675 | — |
| Product | 4-Chloro-6-(cis-3,5-dimethylpiperidino)-5-fluoropyrimidine | HCID 86607460 | — |
| Product | 4-Chloro-6-(trans-3,5-dimethylpiperidino)pyrimidin | HCID 86607469 | — |
Reaction Steps
0.2 g of 4,6-dichloro-5-fluoropyrimidine and 0.41 g of 3,5-dimethylpiperidine (cis/trans diastereomer=about 3/1) were mixed and left for 30 minutes at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.1 g of 4-chloro-6-(cis-3,5-dimethyl piperidino)-5-fluoropyrimidine and 0.05 g of 4-chloro-6-(trans-3,5-dimethylpiperidino)pyrimidin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928110B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-4e983d2cb75344adbd1e0391a4dbd6ff |
| Source note | uspto-grants-2011_04 |