HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyric Acid → 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(isobutyryl-methoxy-amino)-methyl]-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyric Acid | HCID 6590 | — |
| Reactant | 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-(methoxyamino-methyl)-benzamide | HCID 11533581 | — |
| Reactant | 4-oxo-4H-benzo[d][1,2,3]triazin-3-yl isobutyrate | HCID 67076995 | — |
| Product | 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(isobutyryl-methoxy-amino)-methyl]-benzamide | HCID 59348020 | 77% |
Reaction Steps
The title compound was prepared by a procedure similar to that in Example 41. Namely, 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-(methoxyamino-methyl)-benzamide obtained in Example 15 was reacted with 4-oxo-4H-benzo[d][1,2,3]triazin-3-yl isobutyrate prepared from isobutyric acid to give 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(isobutyryl-methoxy-amino)-methyl]-benzamide (88.9 mg, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745663B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-caae24e23c6c4bf4840ba7c8768ec412 |
| Source note | uspto-grants-2010_06 |