HCID 25131530, compound → HCID 25131882, compound

Participants

Reaction Steps

A mixture of 3-{(1R,2R)-2-[(benzyloxy)methyl]-4,4-difluorocyclohexyl}-4-[4-(methylsulfonyl)phenyl]-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl trifluoromethanesulfonate (4.54 g, 6.58 mmol) and 10% palladium on charcoal (2.20 g) were stirred together in ethyl acetate (60 mL) under an atmosphere of hydrogen gas at rt for 16 h. Filtration through Celite®, concentration of the filtrate and flash chromatography on silica gel eluting with 45/55 ethyl acetate/hexanes yielded 3-{(1R,2R)-2-[(benzyloxy)methyl]-4,4-difluorocyclohexyl}-4-[4-(methylsulfonyl)phenyl]-1-(2,2,2-trifluoroethyl)-1H-pyrazole as a colorless, thick syrup.

Provenance & Evidence