Water → HCID 25131532, compound

Participants

Reaction Steps

A solution of {(1R,2R)-5,5-difluoro-2-[4-[4-(methylsulfonyl)phenyl]-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]cyclohexyl}methanol (1.64 g, 3.63 mmol) in acetone (40 mL) was treated at 0° C. with Jones reagent (3.8 mL) followed by stirring at rt for 30 min. Water was added and the mixture was extracted with two portions of ethyl acetate. The combined organics were washed twice with water then with a saturated aqueous solution of NaCl before drying over Na2SO4. Concentration in vacuo gave (1R,2R)-5,5-difluoro-2-[4-[4-(methylsulfonyl)phenyl]-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]cyclohexanecarboxylic acid as a faint-yellow foam.

Provenance & Evidence