Fumaric Acid → HCID 54581792, compound

Participants

Reaction Steps

2-Benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine (792 mg, 3.30 mmol) in hot ethyl acetate (35 ml) was added a solution of fumaric acid (1.0 eq, 384 mgs, 3.30 mmol) in hot methanol (12 ml). The resultant solution was stirred overnight. The solid was collected and recrystallised from ethyl acetate/methanol (30 ml/10 ml). The solid from this was collected by filtration then dried in vacuo to afford the title compound as a colourless solid (982 mg, 91%).

Provenance & Evidence