HCID 59312363, compound → HCID 25070580, compound

Participants

Reaction Steps

Palladium (10% on carbon) (40 mg) was added to a solution of 7-benzyl-4-chloro-2-(1-phenylethyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine (368 mg, 0.97 mmol) of Preparation 30, Step B, in ethyl acetate (5 ml) and hydrogenated at 50° C., 60 psi for 41 h. The reaction mixture was filtered through Arbocel then the filtrate was concentrated in vacuo. The residue was purified by HPLC (Phenomenex column, acetonitrile:water:formic acid gradient) to afford the title compound as an oil in 2% yield, 5 mg.

Provenance & Evidence