Ethanol → HCID 25070908, compound

Participants

Reaction Steps

Palladium hydroxide (20% on carbon) (43 mg, 0.3 mmol) and 1-methyl-1,4-cyclohexadiene (3.42 ml, 30.5 mmol) was added to a solution of 7-benzyl-4-chloro-2-(1-phenylethyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine of preparation 30, Step B, (1.15 g, 3.04 mmol) in ethanol (30 ml) and refluxed, under nitrogen, for 16 h. The reaction mixture was filtered through Arbocel then the filtrate was concentrated in vacuo. The residue was purified by column chromatography on Biotage 40S cartridge, eluting with DCM:MeOH (100:0 to 90:10), to afford the title compound as a solid in 69% yield, 629 mg.

Provenance & Evidence