Ammonium formate → HCID 54583742, compound

Participants

Reaction Steps

Ammonium formate (112 mg, 1.78 mmol) and 10% palladium on carbon (27 mg, 0.27 mmol) was added to a solution of 7-benzyl-4-chloro-2-(2-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine the product of Preparation 31, Step B, (136 mg, 0.36 mmol) in methanol (12 ml) and heated to reflux for 5 h. The reaction mixture was filtered through Arbocel, the filtrate concentrated in vacuo and the residue purified by HPLC (Phenomenex column, acetonitrile:water:formic acid gradient) to afford the title compound as a colourless oil in 11.5% yield, 10.5 mg.

Provenance & Evidence