Ammonium formate → HCID 25070581, compound

Participants

Reaction Conditions

Reaction Steps

Under nitrogen, a mixture of 7-benzyl-4-chloro-2-(4-methylbenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine of Preparation 35, Step B, (150 mg, 0.40 mmol), ammonium formate (250 mg, 4.0 mmol) and 20% palladium on charcoal (15 mg) in ethanol (5 ml) was heated at 75° C. for 1 h. After returning to room temperature, the mixture was filtered through a pad of Arbocel, washing the pad with ethanol. The combined eluates were concentrated in vacuo and the residue purified by column chromatography on silica gel, eluting with dichloromethane:methanol:0.880NH3, 95:5:0.5 then 90:10:1, to afford the title compound as an oil in 85% yield, 85 mg.

Provenance & Evidence