Ammonium formate → HCID 59312310, compound

Participants

Reaction Steps

2,7-Dibenzyl-4-methoxy-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine of Preparation 38, Step C, (75 mg, 0.2 mmol) was dissolved in 10 ml of methanol and ammonium formate (66 mg, 1.04 mmol) and 10% palladium on carbon (20 mg) was added. The reaction was refluxed under nitrogen for 2 h. The reaction mixture was filtered through Arbocel and concentrated in vacuo. The residue was purified by column chromatography on Biotage 40S cartridge, eluting with DCM:MeOH:0.880NH3 (95:5:0.5 to 90:10:1), to afford the title compound as a colourless oil in 100% yield, 56 mg.

Provenance & Evidence