Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) → HCID 59312287, compound

Participants

Reaction Steps

To a solution of tert-butyl 2-[benzyl(methyl)amino]-4-oxo-3,4,5,6,8,9-hexahydro-7H-pyrimido[4,5,d]azepine-7-carboxylate of Preparation 16, Step A (70 mg, 0.19 mmol) in DCM (2 ml) was added trimethyloxonium tetrafluoroborate (3 eq., 84.1 mg, 0.57 mmol) and the mixture was stirred for 2 h. The combined organic layers were combined, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by column chromatography eluting with ethyl actate/pentane (1:3 to 1:1). The relevant fractions were combined and concentrated in vacuo to afford the title compound as a colourless oil (31 mg, 41% yield).

Provenance & Evidence