Butylboronic Acid → HCID 59312257, compound

HRID 2077059Notes

Reaction equation

HRID 2077059 reaction equation
[CH2:1]([C:8]1[N:9]=[C:10](Cl)[C:11]2[CH2:17][CH2:16][N:15]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:14][CH2:13][C:12]=2[N:25]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:27](B(O)O)[CH2:28][CH2:29][CH3:30]>>[CH2:1]([C:8]1[N:9]=[C:10]([CH2:27][CH2:28][CH2:29][CH3:30])[C:11]2[CH2:17][CH2:16][N:15]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:14][CH2:13][C:12]=2[N:25]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 20479Butylboronic AcidHCID 59312273HCID 59312273, compound

Product 1

HCID 59312257HCID 59312257, compound

Procedure

The title compound was prepared using a similar method to that of Preparation 39, starting from 2,7-dibenzyl-4-chloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine of Preparation 38, Step B and n-butaneboronic acid. The title compound was obtained as a colourless oil 126 mg, 79%

Workup

  1. customThe title compound was prepared
  2. customof Preparation 39

Sources & evidence

ORD record
ord-53ed8f937d554f71aa2908b3de524fce
Source dataset
uspto-grants-2011_04
Patent number
US07928099B2

Reaction notes

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