HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2077079Generated: October 27, 2026
Dimethyl Sulfoxide → HCID 67098443, compound
https://huagongshe.com/reaction/2077079
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-(2-Methoxyphenoxy)ethan-1-amine--hydrogen chloride (1/1) | HCID 2762734 | — |
| Reactant | 2-chloro-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile | HCID 11983545 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 67098443 | HCID 67098443 | 14.4% |
Reaction Steps
Compound A (400 mg, 1.63 mmol), 2-(2-methoxyphenoxy)ethylamine hydrochloride (1.10 g) and sodium hydrogencarbonate (1.37 g) were added to DMSO (12 ml), and the mixture was stirred at 100° C. for 27 hr. After stirring, the reaction mixture was added to cold water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and concentrated, and the residue was washed by suspending in ethyl acetate to give the object compound of 2-(2-(2-methoxyphenoxy)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile (89 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07928126B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-e5343d693c0844469a32ddfebbfa8571 |
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| Source note | uspto-grants-2011_04 |
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