HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2077083Generated: October 27, 2026
Dimethyl Sulfoxide → HCID 11949627, compound
https://huagongshe.com/reaction/2077083
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-(Pyridin-3-yloxy)ethanamine | HCID 9793793 | — |
| Reactant | 2-chloro-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile | HCID 11983545 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 11949627 | HCID 11949627 | 138.5% |
Reaction Steps
Compound A (13 g, 53 mmol), 2-(pyridin-3-yloxy)ethylamine (11 g, 80 mmol) and sodium hydrogencarbonate (45 g) were added to DMSO (130 ml), and the mixture was stirred at 130° C. for 20 hr. After stirring, the reaction mixture was added to cold water, and insoluble substance was filtrated (20 g). This was converted to hydrochloride to give the object compound of 2-(2-(pyridin-3-yloxy)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile dihydrochloride (15.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07928126B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-eb8fd9396688484d9adf5635fd6883e7 |
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| Source note | uspto-grants-2011_04 |
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