Dimethyl Sulfoxide → HCID 67097479, compound

Participants

Reaction Conditions

Reaction Steps

Compound C (200 mg, 589 mmol), 2-(2-chlorophenoxy)ethylamine (202 μl) and sodium hydrogencarbonate (495 mg) were added to DMSO (6 ml), and the mixture was stirred at 100° C. for 27 hr. After stirring, the reaction mixture was added to cold water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and concentrated, and the residue was washed by suspending in ethyl acetate. This was converted to hydrochloride to give the object compound of 2-(2-(2-chlorophenoxy)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)-4-(4-methoxyphenyl)nicotinonitrile hydrochloride (12 mg).

Provenance & Evidence