HCID 86617072, compound → HCID 67110408, compound

HRID 2077176Notes

Reaction equation

HRID 2077176 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7](Br)[C:8]2[C:13]([C:14]=1[OH:15])=[C:12]([O:16][C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1)[CH:11]=[CH:10][CH:9]=2)=[O:4].[C:25]([Cu])#[N:26]>>[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]([C:25]#[N:26])[C:8]2[C:13]([C:14]=1[OH:15])=[C:12]([O:16][C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1)[CH:11]=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 86617072HCID 86617072, compoundHCID 178418546HCID 178418546, compound

Product 1

HCID 67110408HCID 67110408, compound

Procedure

The title compound was synthesized from 1-bromo-5-(4-fluoro-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid methyl ester and CuCN in analogy to example 3a; MS-(−)-ion: M−1=337.4.

Sources & evidence

ORD record
ord-f7a6c68b3f1c4bf88cd7e284e04ecad3
Source dataset
uspto-grants-2011_04
Patent number
US07928120B2

Reaction notes

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