HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzofuran → (RS)-2-(1-Benzofuran-2-yl-methanoyl)-4-methyl-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzofuran | HCID 9223 | — |
| Reactant | (RS)-2-(methoxy-methyl-carbamoyl)4-methyl-piperazine-1-carboxylic acid dimethyl-ethyl ester | HCID 86625772 | — |
| Product | (RS)-2-(1-Benzofuran-2-yl-methanoyl)-4-methyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 66968186 | 52% |
Reaction Steps
The title compound (1.81 g, 52%) was prepared from (RS)-2-(methoxy-methyl-carbamoyl)-4-methyl-piperazine-1-carboxylic acid dimethyl-ethyl ester, D54 (2.9 g, 10.1 mmol) and benzofuran (0.74 g, 10.1 mol) using the method of Description 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928124B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-283f5deefcc344f18c3f47e95bade04c |
| Source note | uspto-grants-2011_04 |