2-Fluorobenzenesulphonyl chloride → HCID 57584938, compound

Participants

Reaction Steps

N-(6-(6-Aminopyridin-2-yl)benzo[d]thiazol-2-yl)acetamide (0.220 g, 0.775 mmol) was dissolved in DMSO (3 mL). TEA (0.3 mL, 2 mmol), DMAP (0.020 g, 0.16 mmol), and 2-fluorobenzene-1-sulfonyl chloride (0.4 mL, 3 mmol) were added to the mixture while stirring. The mixture was allowed to stir under inert atmosphere overnight and then it was diluted with DMSO and purified by reverse phase HPLC to give N-(6-(6-(2-fluorophenylsulfonamido)pyridin-2-yl)benzo[d]thiazol-2-yl)acetamide as a yellow solid. MS (ESI pos. ion) m/z: 443 (MH+). Calculated exact mass for C21H15FN4O3S2: 442. 1H NMR (400 MHz, DMSO-d6): 7.99 (s, 1H), 7.94 (t, J=7.3 Hz, 1H), 7.68 (d, J=8.5 Hz, 1H), 7.32-7.47 (m, 3H), 7.28 (t, J=7.5 Hz, 1H), 7.21 (t, J=7.8 Hz, 1H), 7.10 (d, J=7.5 Hz, 1H), 6.41 (d, J=8.5 Hz, 1H), 2.10 (s, 3H).

Provenance & Evidence