反应详情

温度

67.5 °C

2,6-dibromopyridin-3-amine (4.235 g, 16.8 mmol) was dissolved in acetone and acetyl isothiocyanate (1.85 ml, 21.0 mmol) was added. The flask was fit with a reflux condensor and placed in a preheated oil bath (65-70° C.) and stirred under nitrogen for 2.5 hours. Then, the reaction was cooled to room temperature, poured into water, and filtered. The solid was washed with water, saturated sodium bicarbonate, and water again, and then collected and dried under high vacuum to afford N-(5-bromothiazolo[5,4-b]pyridin-2-yl)acetamide (5.54 g, Yield >100%).

1. customplaced in a preheated oil bath
2. temperatureThen, the reaction was cooled to room temperature
3. filtrationfiltered
4. washThe solid was washed with water, saturated sodium bicarbonate, and water again
5. customcollected
6. customdried under high vacuum