Trifluoroacetic acid methylene chloride → HCID 57584956, compound

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Reaction Steps

A mixture of tert-butyl 6-(5-(4-methylphenylsulfonamido)-1,3,4-oxadiazol-2-yl)benzo[d]thiazol-2-ylcarbamate (0.40 g, 0.82 mmol) in 1:1 solution of TFA/CH2Cl2 was stirred at room temperature for 4 hours. The solution was concentrated in vacuo to give the desired product as white solid N-(5-(2-aminobenzo[d]thiazol-6-yl)-1,3,4-oxadiazol-2-yl)-4-methylbenzenesulfonamide (0.30 g, 94% yield). MS (ESI pos. ion) m/z: calc'd for C16H13N5O3S2: 387.0. found: 387.9 (MH+). 1H NMR (300 MHz, MeOH) δ ppm 2.41 (s, 3H) 7.37 (d, J=8.04 Hz, 2H) 7.54 (d, J=8.48 Hz, 1H) 7.82-7.94 (m, 3H) 8.22 (d, J=1.46 Hz, 1H).

Provenance & Evidence