Sodium borohydride → HCID 57584942, compound

Participants

Reaction Steps

To a solution of N-(6-(5-(4-acetylphenylsulfonamido)-6-chloropyridin-3-yl)benzo[d]thiazol-2-yl)acetamide (0.050 g, 0.10 mmol) in THF (5 mL) and MeOH (5 mL) was added sodium borohydride (0.009 mL, 0.3 mmol) at RT. The resultant was stirred at RT for 1 h, and then diluted with 3 mL of water and 1 mL of DMSO. The resultant was filtered. The filterate was subjected to reverse phase HPLC (5-60% CH3CN in water) purification to give a white solid (30 mg, 60%). MS (ESI pos. ion) Found m/z: 541, (M+K)+.

Provenance & Evidence