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HRID2077570

反应详情

EQUATION

反应方程式

HRID 2077570 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：CC(=O)Nc1nc2ccc(B3OC(C)(C)C(C)(C)O3)cc2s1
HCID51354026

未命名化合物

结构：CC(O)c1ccc(S(=O)(=O)Nc2cncc(Br)c2)cc1
HCID67097780

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)Nc1nc2ccc(-c3cncc(NS(=O)(=O)c4ccc(C(C)O)cc4)c3)cc2s1
HCID57584992

未命名化合物

收率 16%

AUXILIARIES

试剂、催化剂与溶剂

4
结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

结构：O
溶剂HCID962

Water

H2O

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

A mixture of N-(5-bromopyridin-3-yl)-4-(1-hydroxyethyl)benzenesulfonamide (0.120 g, 0.34 mmol), N-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazol-2-yl)acetamide (0.11 g, 0.34 mmol), tetrakis(triphenylphosphine)palladium (0.019 g, 0.017 mmol) in 1 ml of dioxane and 1 ml of aq. 2M sodium carbonate was heated under microwave (CEM) at 120 W, 100° C. for 20 min. Then, the resultant was diluted with DCM and water. The organic layer was separated, dried and concentrated. The residue was purified by HPLC (5-60% CH3CN in water gradient) to give a light yellow solid (25 mg, 16%). MS (ESI pos. ion) Found m/z: 469, (M+H)+.

WORKUP

后处理

  1. customThe organic layer was separated
  2. customdried
  3. concentrationconcentrated
  4. customThe residue was purified by HPLC (5-60% CH3CN in water gradient)