HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-(6-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Aminotetrahydropyran | HCID 419223 | — |
| Reactant | N-(6-(2-Chloropyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide | HCID 51357685 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-(6-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide | HCID 57585019 | 23.2% |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
A mixture of N-(6-(2-chloropyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide (0.200 g, 0.7 mmol), 4-aminotetrahydropyran (0.07 ml, 0.7 mmol), N-ethyl-N-isopropylpropan-2-amine (0.2 g, 1 mmol) in DMSO (1 g, 13 mmol) was heated under microwave (CEM) at 150° C. and 130 W (Powermax®& off) for 40 min. Then, the mixture was diluted with 1 ml of DMSO and purified by HPLC (5-50% CH3CN in water) to give a light yellow solid (60 mg) as a TFA salt. MS (ESI pos. ion) Found m/z: 370, (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928140B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-9152d1f1049e468f9d555d3c61460823 |
| Source note | uspto-grants-2011_04 |