HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopyridine → N-(6-(2-(pyridin-2-ylamino)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopyridine | HCID 10439 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-(6-(2-Chloropyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide | HCID 51357685 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-(6-(2-(pyridin-2-ylamino)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide | HCID 57584988 | 9.2% |
Reaction Conditions
| Temperature | 180 °C |
|---|
Reaction Steps
A mixture of N-(6-(2-chloropyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide (0.100 g, 0.3 mmol), pyridin-2-amine (0.03 g, 0.3 mmol), N-ethyl-N-isopropylpropan-2-amine (0.1 g, 1.0 mmol) in DMSO (1 g, 13 mmol) was heated under microwave (CEM) at 180° C. and 200 W (Powermax® off). Then, the mixture was diluted with 1 ml of DMSO and purified by HPLC to give a light yellow solid (10 mg). MS (ESI pos. ion) Found m/z: 363, (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928140B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-46a7c290ec27474aa6aea091d69fd59a |
| Source note | uspto-grants-2011_04 |