Methoxyacetyl chloride → HCID 57585051, compound

Participants

Reaction Steps

A mixture of 6-(6-chloro-5-(dimethylamino)pyridin-3-yl)benzo[d]thiazol-2-amine (54 mg, 177 μmol) and 2-methoxyacetyl chloride (25 mg, 230 μmol) in DCM-pyridine (0.5 mL each) was stirred at rt. More 2-methoxyacetyl chloride (25 mg, 230 μmol) was added after overnight, resulting in a solution. The reaction was complete after 1 h. The mixture was concentrated, and diluted with NaHCO3 (saturated, 5 mL). After agitating for 30 min, the mixture was filtered, and washed with H2O (3×3 mL) to give a green solid (55 mg, 82%). LCMS: calc'd for C17H17ClN4O2S:376.0. found: 377.1. 1H NMR (400 MHz, DMSO-d6) δ ppm 2.86 (s, 6H) 3.32 (s, 3H) 4.23 (s, 2H) 7.76-7.88 (m, 3H) 8.36 (s, 1H) 8.43 (s, 1H) 12.39 (s, 1H).

Provenance & Evidence