HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → 2-(6-Aminopyridin-3-yl)ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Ethyl 2-(6-nitropyridin-3-yl)acetate | HCID 21300451 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(6-Aminopyridin-3-yl)ethan-1-ol | HCID 21876349 | — |
Reaction Steps
To a solution of ethyl (6-nitro-3-pyridinyl)acetate (468 mg, 2.60 mmol) in tetrahydrofuran was added LiAlH4 and stirred for 2 h at room temperature. The reaction was quenched with saturated 25% NH3 aqueous solution and the precipitate was removed. The filtrate was concentrated to give a title compound as yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928119B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-87da96822bbf42c9b4e6ea6239dea6e5 |
| Source note | uspto-grants-2011_04 |