反应详情

Methyl N-((6-chloro-4-hydroxy-1,1-dimethyl-2-oxo-naphthalene-3-yl)carbonyl)glycinate (0.256 g, 0.760 mmol) was suspended in water (3.0 mL) and treated with a 5N NaOH solution (0.38 mL, 1.90 mmol). After 20 minutes at ambient temperature, the resulting homogeneous mixture was quenched with a 1N HCl solution to pH=2. The white solid that precipitated upon acidification was collected by vacuum filtration and washed with 1:1 H2O/acetone (2×2.0 mL). The product was subsequently dried at 80° C. under vacuum for 24 hours. MS m/e=324.0 (M+H)+. Calculated for C15H14ClNO5 323.06.

1. customthe resulting homogeneous mixture was quenched with a 1N HCl solution to pH=2
2. customThe white solid that precipitated upon acidification
3. filtrationwas collected by vacuum filtration
4. washwashed with 1:1 H2O/acetone (2×2.0 mL)
5. customThe product was subsequently dried at 80° C. under vacuum for 24 hours