HCID 67099645, compound → HCID 54746529, compound

Participants

Reaction Steps

A solution of 1,1-dimethylethyl N-((4-hydroxy-2-oxo-6-(trifluoromethyl)-2′,3′,5′,6′-tetrahydro-spiro[naphthalene-1,4′-pyran]-3-yl)carbonyl)glycinate (500 mg, 1098 μmol) in TFA (4 mL) was stirred at 23° C. After 25 minutes, the reaction was concentrated in vacuo and azeotroped with DCM (2×10 mL). The crude solid was washed with diethyl ether affording 356 mg of N-((4-hydroxy-2-oxo-6-(trifluoromethyl)-2′,3′,5′,6′-tetrahydro-2H-spiro[naphthalene-1,4′-pyran]-3-yl)carbonyl)glycine. MS m/e=400.1 (M+H)+. Calculated for C18H16F3NO6 399.09.

Provenance & Evidence