Diisopropylethylamine → HCID 67099874, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 6-chloro-4-ethyl-1-hydroxy-4-methyl-3-oxo-naphthalene-2-carboxylate (0.5 g, 2 mmol), and tert-butyl 2-aminoacetate hydrochloride (0.4 g, 2 mmol) in 5 mL dioxane, was treated with N-ethyl-N-isopropylpropan-2-amine (0.6 g, 5 mmol). The resulting mixture was warmed to 95° C. and stirred for 4 hours, M+Na=416, M−1=392. The mixture was then cooled to room temperature and concentrated in vacuo. The crude product was purified by column chromatography eluting with 10-20% EtOAc/hexane to give 0.44 g of the title compound as a white yellow solid. MS m/e=416 (M+Na)+.

Provenance & Evidence