HCID 67099769, compound → HCID 67099664, compound

Participants

Reaction Steps

To 20 mL concentrated H2SO4 stirred at room temperature, was added diethyl 2-(2-(2-fluoro-3-hydroxyphenyl)-2-methylpropanoyl)malonate (3.6 g, 11 mmol). The mixture was stirred at room temperature for 2 hours, M+1=295. The mixture was then poured into 100 g crushed ice and extracted with EtOAc (3×50 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous Na2SO4, concentrated in vacuo, and purified by column chromatography eluting with 10-30% EtOAc/hexane to give 2.9 g of the title compound as a pale yellow solid. MS (m/z)=295 (M+H)+.

Provenance & Evidence