HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 2-(2-Iodophenyl)propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 2-Iodophenylacetonitrile | HCID 4402282 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(2-Iodophenyl)propanenitrile | HCID 66855147 | — |
Reaction Steps
2-(2-Iodophenyl)acetonitrile (3.0 g, 12 mmol) and sodium tert-butoxide (3.6 g, 37 mmol) were stirred in 20 mL of DMF, and MeI (0.77 mL, 12 mmol) was added dropwise. The reaction was then stirred for 3 hours. The solvent was removed under vacuum. The crude residue was purified by silica flash chromatography 0-15% EtOAc/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928139B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-17edfcb0b19d4741bf6fb33acd7f2e9b |
| Source note | uspto-grants-2011_04 |