Sulfuric Acid → HCID 67100083, compound

Participants

Reaction Steps

Diethyl 2-(4-(3-chlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate (10.66 g, 27.8 mmol) was added to H2SO4 (50 mL, 591 mmol), and the mixture was stirred at room temperature for 1 hour. Ice (H2O) was added, and the aqueous mixture was extracted with EtOAc (2×). The combined organic layers were washed with water (2×) and brine, dried (MgSO4), and concentrated in vacuo to give the crude compound as an orange oil. The crude oil was purified by silica flash chromatography (0-100% DCM/hexane) to give the desired compound as a yellow solid (4.93 g). MS (m/e)=337.1 (M+H)+.

Provenance & Evidence