Sulfuric Acid → HCID 67100079, compound

Participants

Reaction Conditions

Reaction Steps

P2O5 (4.45 g, 31.3 mmol) was added to H2SO4 (4.17 mL, 78.3 mmol), the mixture was cooled to 0° C., and diethyl 2-(4-(3,4-difluorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate (3.01 g, 7.83 mmol) was added at 0° C. The reaction mixture was stirred for 4 hours and then poured into ice, diluted with 200 mL of EtOAc, added to a separatory funnel, partitioned with water, washed 2 times with 75 mL of water, separated, dried over Na2SO4, and concentrated in vacuo to give the title compound which was used without further purification. MS (m/z)=339 (M+H)+.

Provenance & Evidence