Diisopropylethylamine → HCID 67099753, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 2-aminoacetate hydrochloride (901 mg, 5376 μmol) was added to a mixture of ethyl 6′-chloro-4′-hydroxy-2′-oxo-spiro[cyclohexane-1,1′-naphthalene]-3′-carboxylate (1.20 g, 3584 μmol) in 1,4-dioxane (3584 μL) and N-ethyl-N-isopropylpropan-2-amine (1873 μL, 10753 μmol). The resulting mixture was heated at 80° C. for 2 hours. The resulting mixture was then diluted with 100 mL of EtOAc, added to a separatory funnel, partitioned with NaHCO3 (saturated, aqueous), washed 2 times with 50 mL of NaHCO3 (saturated, aqueous), separated, dried over Na2SO4, and concentrated in vacuo to give the title compound (185 mg) as a light yellow solid after purification via preparatory HPLC. MS (m/z)=364 (M+H-tBu)+.

Provenance & Evidence