HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-((5-Chloro-4-hydroxy-1,1-dimethyl-2-oxo-naphthalen-3-yl)carbonyl)glycine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl N-((5-chloro-4-hydroxy-1,1-dimethyl-2-oxo-naphthalen-3-yl)carbonyl)glycinate | HCID 86629259 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-((5-Chloro-4-hydroxy-1,1-dimethyl-2-oxo-naphthalen-3-yl)carbonyl)glycine | HCID 57983417 | 97.2% |
Reaction Steps
tert-Butyl N-((5-chloro-4-hydroxy-1,1-dimethyl-2-oxo-naphthalen-3-yl)carbonyl)glycinate (204 mg, 537 μmol) was stirred in TFA (2 mL, 26924 μmol) for 25 minutes. Water was added. The resulting precipitate was filtered and washed with water to give a white solid (169 mg). MS m/e=324 (M+H)+. Calculated for C15H14ClNO5 323.06.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928139B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-e108a4db71ca42aea27a84ac766dc6ad |
| Source note | uspto-grants-2011_04 |