Sulfuric Acid → HCID 67100100, compound

Participants

Reaction Steps

P2O5 (12.5 g, 88.1 mmol) was mixed with concentrated H2SO4 (11.2 mL, 81.3 mmol) at 0° C., and the resulting mixture was stirred for 30 minutes. Diethyl 2-(2-(3-chloro-2-fluorophenyl)-2-methylpropanoyl)malonate (1.00 g, 2.48 mmol) was added to the reaction, and the resulting mixture was stirred at 25° C. for 1 hour. The resulting mixture was quenched with ice, and, on melting, was extracted with EtOAc (3×100 mL). The combined organic layers were washed with brine (100 mL), dried over MgSO4, concentrated, and dried in vacuo to give crude ethyl 7-chloro-8-fluoro-4-hydroxy-1,1-dimethyl-2-oxo-naphthalene-3-carboxylate (0.470 g). MS m/e=313 (M+H)+.

Provenance & Evidence