Sulfuric Acid → HCID 67099917, compound

Participants

Reaction Conditions

Reaction Steps

Diethyl 2-(4-phenyl-tetrahydro-2H-pyran-4-carbonyl)malonate (418 mg, 1200 μmol) was dissolved in a minimal amount of EtOAc and then cooled to 0° C. A slurry of P2O5 (681 mg) and H2SO4 (640 μL, 11998 μmol) (also at 0° C.) was added to the mixture via spatula, and the reaction mixture was stirred for 3 hours. The reaction mixture was then poured into a beaker of ice, diluted with 100 mL of EtOAc, added to a separatory funnel, partitioned with water, washed with water (2×50 mL), separated, dried over Na2SO4, and concentrated in vacuo to give the title compound which was used without further purification. MS m/e=303 (M+H)+.

Provenance & Evidence