Diisopropylethylamine → HCID 67099828, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 4-hydroxy-2-oxo-2′,3′,5′,6′-tetrahydro-spiro[naphthalene-1,4′-pyran]-3-carboxylate (450 mg, 1488 μmol) was dissolved in 1,4-dioxane (1488 μL) and N-ethyl-N-isopropylpropan-2-amine (778 mL, 4465 μmol). tert-Butyl 2-aminoacetate hydrochloride (374 mg, 2233 μmol) was added, and the mixture was heated at 80° C. for 3 hours. The resulting mixture was then cooled to ambient temperature, diluted with 100 mL of EtOAc, added to a separatory funnel, partitioned with NaHCO3 (saturated, aqueous), washed with NaHCO3 (saturated, aqueous) (2×75 mL), separated, dried over Na2SO4, and concentrated in vacuo to give the title compound (270 mg) as a white solid. MS m/e=388 (M+H)+.

Provenance & Evidence