Water → HCID 178517755, compound

Participants

Reaction Steps

At room temperature, bromine (1.2 mL, 24 mmol) was added dropwise to a solution of 5-chloro-2-pyridinol (2.9 g, 20 mmol) in glacial acetic acid (25 mL). After stirred at room temperature overnight, ethyl acetate and water were added. The organic layer was washed with water, dried and concentrated. The residue was triturated with diethyl ether and the precipitate was filtered and dried to give the title compound (1.5 g).

Provenance & Evidence