Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | — |
| Reactant | HCID 59443772 | HCID 59443772 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86644169 | HCID 86644169 | 78.9% |
Reaction Steps
To the mixture of 6-chlorooxindole (4.9 g, 29.3 mmol) and 2-(5-Chloro-3-formyl-pyridin-2-yloxy)-2-methyl-propionic acid methyl ester (7.2 g, 28 mmol) in methanol (50 mL) was added pyrrolidine (2.3 mL, 28 mmol) dropwise. The mixture was then heated at 70° C. for 1 h. After cooled to room temperature, the mixture was filtered and the precipitate was collected, dried to give title compound as a yellow solid (9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07928233B2 |
|---|
| Source dataset | uspto-grants-2011_04 |
|---|
| ORD ID | ord-e4f02f13eeea41328762b288ace9aeb0 |
|---|
| Source note | uspto-grants-2011_04 |
|---|
