反应详情

BBr3 (6.61 g, 0.0264 mol) was added to 3,5-difluoro-4-methoxybenzonitrile (1.5 g, 0.0088 mol; see step (iii) above) in dichloromethane (15 mL) at −78° C. Stirring was continued at room temperature overnight under a nitrogen atmosphere. The reaction mixture was then quenched with ice water and extracted with dichloromethane. The organic layer was washed with water and brine, and dried over sodium sulfate. Solvent evaporation under reduced pressure yielded 1.1 g (80.6%) of the sub-title compound as a grey solid.

1. customThe reaction mixture was then quenched with ice water
2. extractionextracted with dichloromethane
3. washThe organic layer was washed with water and brine
4. dry with materialdried over sodium sulfate
5. customSolvent evaporation under reduced pressure