Potassium Carbonate → HCID 86628044, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-(2-bromoethoxy)-3-fluorobenzonitrile (21.6 g, 0.0885 mol; see step (v) above), 9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (21.1 g, 0.07965 mol; see WO 01/28992) and dry K2CO3 (48.9 g, 0.354 mol) in 200 mL of dry acetonitrile was stirred at 60° C. for five days under a nitrogen atmosphere. The reaction mixture was filtered through Celite® and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography over silica gel, using 27% ethyl acetate in petroleum ether as eluent, to yield 20.5 g of the sub-title compound as a solid.

Provenance & Evidence