Potassium Carbonate → {3-[7-(4-Cyano-benzyl)-9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl]-propyl}-carbamic acid tert-butyl ester

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-(9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl-methyl)benzonitrile hydrochloride (6.8 g, 0.021 mol; see Preparation J above), tert-butyl (3-bromopropyl)carbamate (3.93 g, 0.017 mol; see Preparation I above) and dry K2CO3 (8.24 g, 0.059 mol) in 27 mL of dry acetonitrile was stirred at 60° C. overnight under a N2 atmosphere. The reaction mixture was filtered through Celite® and the filtrate was concentrated under reduced pressure to give 7.5 g of the sub-title compound as pale a liquid.

Provenance & Evidence